Factors Influencing Success In Ovum Donation
The relationship between the embryo and the endometrium can be regarded as a “seed-soil” relationship. An optimal “soil-seed relationship” is central to successful procreation regardless of whether it occurs naturally, following ovulation induction, with conventional IVF or as from IVF with ovum donation.Optimal egg/embryo quality is largely influenced by the age of the egg provider, and the method of ovarian stimulation, uterine receptivity is governed by appropriate endometrial development in response to hormonal therapy in the absence of uterine surface lesions, endometrial TH1 cytokinopathies and ureaplasma infection. These factors coupled with embryo transfer technique impact significantly on outcome with IVF/ovum donation. The age of the recipient plays hardly any role at all.
The Influence Of Age On Outcome
While conventional IVF birth rates decline with increasing age of the mother, the birth rate in ovum donor recipients remains relatively constant in all age categories. It is age of the egg provider that influences outcome, regardless of the method of conception. Natural conception rates, conception following intrauterine insemination and conventional IVF conception rates all decline with advancing age of the woman while this is not so in embryo recipients where the egg provider is consistently of a younger age.
The miscarriage rate increases with the age of the egg provider rather than with advancing age of the recipient of embryos derived from donor eggs. Advancing age is associated with an increased incidence of miscarriage following natural conception, IUI and conventional IVF while the incidence of miscarriage remains constant regardless of the advancing age of the embryo recipient.
New York Fertility Services Egg Donation Success Rates Table (SART.org)